Human chorionic gonadotropin (HCG) is commonly detected in placental cells during pregnancy and can be synthesized as a human peptide. Its primary role is to support placental development. However, HCG has shown additional benefits according to research findings. It has been found to enhance male fertility by restoring testosterone production and treating infertility and low sperm count. Furthermore, HCG has been investigated for its potential in weight loss due to its ability to suppress the hunger hormone.

Numerous clinical trials and studies have explored the potential uses of HCG. In this section, we will highlight some noteworthy research findings.

HCG and its Potential in Addressing Hypogonadism HCG has long been considered as a potential treatment for hypogonadism, which involves low testosterone levels and infertility. This is attributed to HCG's ability to stimulate testosterone production and enhance sperm count, thereby potentially alleviating infertility.

A trial from 2019 found that using hCG to treat hypogonadal symptoms in men with a baseline testosterone level above 300 ng/dL could potentially be safe and effective without adverse events. Another study from 2018 demonstrated that hCG, whether administered alone or in combination with testosterone, could help men with hypogonadism maintain their fertility and potentially restore sperm production and count.

Potential to Improve Testosterone Deficiency According to the American Urology Association (AUA), doctors and clinicians should consider a total testosterone level below 300 ng/dL as the threshold for diagnosing hypogonadism and considering testosterone replacement therapy.

HCG acts as an analog of Luteinizing Hormone (LH), which is naturally produced in the pituitary gland and signals the testicles to produce more testosterone. By using HCG, it is possible to stimulate the body's natural up-regulation of testosterone production.

A small study from 2019 reviewed the clinical charts of 37 men with symptoms of low libido, low energy, erectile dysfunction, and insomnia, whose serum testosterone levels were above 300 ng/dL. These men received HCG as a potential treatment. HCG monotherapy demonstrated the potential to increase testosterone levels by up to 263 ng/dL (42.8%). While the study did not primarily focus on symptom improvement, the use of HCG to potentially raise testosterone levels was evident.

HCG and Sexual Dysfunction In a double-blind, placebo-controlled study conducted on forty-five individuals experiencing nonorganic sexual desire disorders, subjects were treated with either human chorionic gonadotropins or a placebo for one month. The study revealed that HCG potentially yielded better results compared to the placebo and improved a higher number of sexual parameters. This suggests that HCG could be a valuable option for sexological treatment of erectile failure and low sex drive.